UK 78282 hydrochloride

Tocris Bioscience | Catalog # 3829

Blocker of KV1.3 and KV1.4 channels
Tocris Bioscience

Key Product Details

Description

Blocker of KV1.3 and KV1.4 channels
View all Voltage-gated Potassium Channel Blockers »

Product Description

UK 78282 hydrochloride is a blocker of the KV1.3 and KV1.4 voltage-gated potassium channels in T lymphocytes (IC50 values are 0.28 and 0.17 μM respectively). Suppresses T lymphocyte mitogenesis; leads to membrane depolarization. Also blocks KV1.4 expressed in heart and brain.

Product Specifications for UK 78282 hydrochloride

Molecular Weight

466.05

Formula

C29H35NO2.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine hydrochloride

CAS Number

136647-02-4

PubChem ID

53393337

InChI Key

ZZSQARULZYQMIG-UHFFFAOYSA-N

SMILES

COC(C=C3)=CC=C3CCCN1CCC(COC(C4=CC=CC=C4)C2=CC=CC=C2)CC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.3 50
Ethanol 13.98 30

Preparing Stock Solutions for UK 78282 hydrochloride

The following data is based on the product molecular weight 466.05.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.29 mL 21.46 mL 42.91 mL
2.5 mM 0.86 mL 4.29 mL 8.58 mL
5 mM 0.43 mL 2.15 mL 4.29 mL
25 mM 0.09 mL 0.43 mL 0.86 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for UK 78282 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for UK 78282 hydrochloride

For research use only

Citations for UK 78282 hydrochloride

Customer Reviews for UK 78282 hydrochloride (1)

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  • Voltage gated Kv channel blocker with amazing research potential
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/15/2018
    Voltage gated Kv channel blocking can be assessed under lab conditions with this product. UK 78782 is an excellent compound to get an understanding of channel blocking of different kind of Kv channel. Was dissolved in ethanol and easy to carry out HPLC on.
    UK 78282 hydrochloride 3829

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