UK 78282 hydrochloride
Chemical Name: 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine hydrochloride
Biological ActivityUK 78282 hydrochloride is a blocker of the KV1.3 and KV1.4 voltage-gated potassium channels in T lymphocytes (IC50 values are 0.28 and 0.17 μM respectively). Suppresses T lymphocyte mitogenesis; leads to membrane depolarization. Also blocks KV1.4 expressed in heart and brain.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation.
Hanson et al.
Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants.
Chandy et al.
K+ channels as targets for specific immunomodulation.
Chandy et al.
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Voltage gated Kv channel blocking can be assessed under lab conditions with this product. UK 78782 is an excellent compound to get an understanding of channel blocking of different kind of Kv channel. Was dissolved in ethanol and easy to carry out HPLC on.