Catalog Number: 3829
Chemical Name: 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine hydrochloride
Biological Activity
Blocker of the KV1.3 and KV1.4 voltage-gated potassium channels in T lymphocytes (IC50 values are 0.28 and 0.17 μM respectively). Suppresses T lymphocyte mitogenesis; leads to membrane depolarization. Also blocks KV1.4 expressed in heart and brain.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO and to 30 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation.
    Hanson et al.
    Br.J.Pharmacol., 1999;126:1707
  2. Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants.
    Chandy et al.
    Toxicon, 2001;39:1269
  3. K+ channels as targets for specific immunomodulation.
    Chandy et al.
    Trends.Pharmacol.Sci., 2004;25:280
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