Negative control of UNC 1999
(Cat. No. 4904). Exhibits 1000-fold lower potency than active analog (IC50
values are 62 and >200 μ
M for EZH1 and EZH2, respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 1999 probe summary
on the SGC website.
Other Product-Specific Information:
An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1.
Konze et al.
ACS Chem.Biol., 2013;8:1324
Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia.
Xu et al.