Chemical Name: N-[(1,2-Dihydro-1,6-dimethyl-2-oxo-4-propyl-3-pyridinyl)methyl]-N-methyl-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-1H-indazole-4-carboxamide
Biological ActivityUNC 2400 is a negative control of UNC 1999. Exhibits 1000-fold lower potency than active analog (IC50 values are 62 and >200 μM for EZH1 and EZH2, respectively).
Active Analog also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1.
Konze et al.
ACS Chem.Biol., 2013;8:1324
Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia.
Xu et al.
Citation for UNC 2400
The citations listed below are publications that use Tocris products. Selected citations for UNC 2400 include:
1 Citation: Showing 1 - 1
SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells.
Authors: Chagraoui Et al.
Nat Commun 2018;9:5375
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