UNC 1999

Tocris Bioscience | Catalog # 4904

Potent and selective EZH2/EZH1 inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective EZH2/EZH1 inhibitor
View all EZH2 Inhibitor »

Product Description

UNC 1999 is a potent and SAM-competitive EZH2/EZH1 lysine methyltransferase inhibitor (IC50 values are 10 and 45 nM, respectively). Selective for EZH2/EZH1 over a panel of other methyltransferases and non-epigenetic targets. Reduces H3K27me3 levels in vitro. Prolongs survival of MLL-AF9 bearing mice. Orally bioavailable.

Negative Control also available.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 1999 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of UNC 1999 is reviewed on the chemical probes website.

Product Specifications for UNC 1999

Molecular Weight

569.74

Formula

C33H43N7O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-1H-indazole-4-carboxamide

CAS Number

1431612-23-5

PubChem ID

72551585

InChI Key

DPJNKUOXBZSZAI-UHFFFAOYSA-N

SMILES

CC(C)N1CCN(C2=NC=C(C3=CC(N(C(C)C)N=C4)=C4C(C(NCC5=C(CCC)C=C(C)NC5=O)=O)=C3)C=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.39 20
1M HCl 56.97 100

Preparing Stock Solutions for UNC 1999

The following data is based on the product molecular weight 569.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.76 mL 8.78 mL 17.55 mL
5 mM 0.35 mL 1.76 mL 3.51 mL
10 mM 0.18 mL 0.88 mL 1.76 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 17 publications citing the usage of this product.

Product Documents for UNC 1999

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for UNC 1999

For research use only

Related Research Areas

Cancer Biomarkers
Epigenetics

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