UNC 6852

Key Product Details

Product Description

UNC 6852 is a polycomb repressive complex 2 (PRC2) Degrader (PROTAC^®; DC₅₀ = 0.79 μM). It comprises an EED (embryonic ectoderm development) based ligand, joined by a linker to a von Hippel-Lindau ligand. In B lymphoblast cell lines, UNC 6852 selectively degrades PRC2 components EED (DC₅₀ = 0.31 μM, D_max = 94%), enhancer of zeste homolog 2 (EZH2, DC₅₀ = 0.67 μM, D_max = 96%), and suppressor of zeste homolog 12 (SUZ12, DC₅₀ = 0.59 μM, D_max = 82%). In zebrafish, UNC 6852 treatment increases transcription of tfpia and prolongs time to occlusion (TTO) in the caudal vein following laser injury.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for UNC 6852

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for UNC 6852

The following data is based on the product molecular weight 832.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.20 mL	6.00 mL	12.01 mL
5 mM	0.24 mL	1.20 mL	2.40 mL
10 mM	0.12 mL	0.60 mL	1.20 mL
50 mM	0.02 mL	0.12 mL	0.24 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Raman Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Sci.Rep. 2021 PMID: 34315984
• Potjewyd Degradation of polycomb repressive complex 2 with an EED-targeted bivalent chemical degrader. Cell Chem.Biol. 2020 PMID: 31831267

Product Documents for UNC 6852