UNC 6934

Key Product Details

Product Description

UNC 6934 binds to the N-terminal proline-tryptophan-tryptophan-proline (PWWP) domain of nuclear receptor-binding SET domain-containing 2 (NSD2). UNC 6934 inhibits PWWP1 interaction with nucleosomal H3K36me2 (IC₅₀ = 104 nM) by occupying the canonical H3K36me2-binding pocket of PWWP1. It selectively binds endogenous NSD2 in cells and causes accumulation of endogenous NSD2 in the nucleolus.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 6934 probe summary on the SGC website.

Product Specifications for UNC 6934

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for UNC 6934

The following data is based on the product molecular weight 443.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.27 mL	56.37 mL	112.75 mL
1 mM	2.25 mL	11.27 mL	22.55 mL
2 mM	1.13 mL	5.64 mL	11.27 mL
10 mM	0.23 mL	1.13 mL	2.25 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Sankaran A PWWP domain of histone-lysine N-methyltransferase NSD2 binds to dimethylated Lys-36 of histone H3 and regulates NSD2 function at chromatin. J.Biol.Chem. 2016 PMID: 26912663
• Dilworth A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nat.Chem.Biol. 2022 PMID: 34782742

Product Documents for UNC 6934