UNC 8732

Key Product Details

Product Description

UNC 8732 is a potent nuclear receptor binding SET domain-containing 2 (NSD2) Degrader (DC₅₀ = 60 nM; D_max = 97%). NSD2 degradation is driven by the aldehyde metabolite of UNC 8732 in vitro. Recruits FBX022 and SCF complexes for degradation to reduce H3K36me2 levels in cells. Reduces viability and restores glucocorticoid sensitivity of NSD2 p.E1099K mutant ALL cells.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC8732 page on the SGC website.

Product Specifications for UNC 8732

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for UNC 8732

The following data is based on the product molecular weight 723.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.38 mL	6.91 mL	13.82 mL
5 mM	0.28 mL	1.38 mL	2.76 mL
10 mM	0.14 mL	0.69 mL	1.38 mL
50 mM	0.03 mL	0.14 mL	0.28 mL

Calculators

Background References

References are publications that support the biological activity of the product.

There are currently no references for this product.

Product Documents for UNC 8732