Chemical Name: (1S,2S)-2-(3,4-Dichlorobenzoyl)cyclopropanecarboxylic acid
Biological ActivityUPF 648 is a potent kynurenine 3-monooxygenase (kynurenine 3-hydroxylase; KMO) inhibitor (IC50 = 20 nM). Increases kynurenic acid levels, and decreases 3-HK and QUIN levels in cerebrum and liver of neonatal rodents. Neuroprotective in a Drosophila model of Huntington's disease.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications.
Ceresoli-Borroni et al.
Structural basis of kynurenine 3-monooxygenase inhibition.
Amaral et al.
On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo.
Amori et al.
The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease.
Campesan et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for UPF 648
There are currently no reviews for this product. Be the first to review UPF 648 and earn rewards!
Have you used UPF 648?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image