UPF 648
Chemical Name: (1S,2S)-2-(3,4-Dichlorobenzoyl)cyclopropanecarboxylic acid
Purity: ≥98%
Biological Activity
UPF 648 is a potent kynurenine 3-monooxygenase (kynurenine 3-hydroxylase; KMO) inhibitor (IC50 = 20 nM). Increases kynurenic acid levels, and decreases 3-HK and QUIN levels in cerebrum and liver of neonatal rodents. Neuroprotective in a Drosophila model of Huntington's disease.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications.
Ceresoli-Borroni et al.
J.Neurosci.Res., 2007;85:845 -
Structural basis of kynurenine 3-monooxygenase inhibition.
Amaral et al.
Nature, 2013;496:382 -
On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo.
Amori et al.
J.Neurochem., 2009;109:316 -
The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease.
Campesan et al.
Curr.Biol., 2011;21:961
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