V 9302 hydrochloride

Key Product Details

Product Description

V 9302 hydrochloride is an alanine-serine-cysteine transporter 2 (ASCT2, encoded by gene SLC1A5) inhibitor. It inhibits glutamate uptake (IC₅₀ = 9.6 μM in HEK-293 cells). It reduces cancer cell growth and proliferation, also increases cell death and oxidative stress in vitro and in vivo. V 9302 hydrochloride inhibits mTORC1 activity, mitochondrial respiration, proliferation and migration of vascular smooth muscle cells (VSMCs).

Licensing Information

Sold under license from Vanderbilt University

Product Specifications for V 9302 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for V 9302 hydrochloride

The following data is based on the product molecular weight 575.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.48 mL	17.39 mL	34.77 mL
2.5 mM	0.70 mL	3.48 mL	6.95 mL
5 mM	0.35 mL	1.74 mL	3.48 mL
25 mM	0.07 mL	0.35 mL	0.70 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Park V-9302 inhibits proliferation and migration of VSMCs, and reduces neointima formation in mice after carotid artery ligation. Biochem.Biophys.Res.Commun. 2021 PMID: 33965788
• Li Inhibitor of glutamine metabolism V9302 promotes ROSinduced autophagic degradation of B7H3 to enhance antitumor immunity. J.Biol.Chem. 2022 PMID: 35189139
• Schulte Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. Nat.Med. 2018 PMID: 29334372

Product Documents for V 9302 hydrochloride