Catalog Number: 2918
Chemical Name: 4α,9-Epoxy-3β-veratroyloxy-5β-cevan-4β,12,14,16β,17,20-hexaol
Biological Activity
Voltage-gated Na+ channel opener; increases intracellular Ca2+ with no effect on the Na+/Ca2+ exchanger. Steroid-derived alkaloid neurotoxin. Increases membrane Na+ permeability and depolarizes excitable tissues.
Technical Data
  • M.Wt:
    673.79
  • Formula:
    C36H51NO11
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    71-62-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Purification, solubility and pKa of veratridine.
    McKinney et al.
    Anal.Biochem., 1986;153:33
  2. Effects of Ca2+ channel antagonists on chromaffin cell death and cytosolic Ca2+ oscillations induced by veratridine.
    Maroto et al.
    Eur.J.Pharmacol., 1994;270:331
  3. Mechanism of the persistant sodium current activator veratridine-evoked Ca2+ elevation: implication for epilepsy.
    Fekete et al.
    J.Neurochem., 2009;111:745
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Veratridine include:

2 Citations: Showing 1 - 2
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  1. Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequency activity.
    Authors: Battefeld Et al.
    Biol Psychiatry 2016;7:11298
  2. Neural progenitors organize in small-world networks to promote cell proliferation.
    Authors: Malmersjö Et al.
    Nat Commun 2013;110:E1524

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