VH 032 amide-alkylC7-amine

Tocris Bioscience | Catalog # 7074

VHL ligand with alkyl linker and terminal amine for onward chemistry
Tocris Bioscience

Key Product Details

Description

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternative Names

(S,R,S)-AHPC-C7-NH2
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Product Description

VH 032 amide-alkylC7-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand plus an alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used. This product is sold as an xHCl salt. The stoichiometry of the salt and hydration levels vary from batch to batch. It is sold in gross weight with the batch specific Molecular Weight available on the Certificate of Analysis

Product Specifications for VH 032 amide-alkylC7-amine

Formula

C30H45N5O4S.xHCl

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

(2S,4R)-1-((S)-2-(8-Aminooctanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride

InChI Key

RMNLYSBBFGSMFL-QVRKWNSCSA-N

SMILES

CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCCCCN)=O)=O)O)=O)SC=N1.Cl.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 37 publications citing the usage of this product.

There are currently no references for this product.

Product Documents for VH 032 amide-alkylC7-amine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for VH 032 amide-alkylC7-amine

For research use only

Citations for VH 032 amide-alkylC7-amine

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