VH 032 amide-PEG2-alkyne

Catalog # Availability Size / Price Qty
VH 032 amide-PEG2-alkyne | CAS No. 2098799-80-3 | Degrader Building Blocks
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Description: VHL ligand with PEG linker and terminal alkyne for onward chemistry
Alternative Names: VH 032 - linker 6

Chemical Name: (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-6,9,12-trioxa-3-azapentadec-14-yn-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Product Details

Biological Activity

Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand plus PEG2 linker with terminal alkyne ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was VH 032 - linker 6

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in DMF
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Selective small molecule induced degradation of the BET bromodomain protein BRD4.
    Zengerle et al.
    ACS Chem.Biol., 2015;10:1770
  2. Waste disposal-An attractive strategy for cancer therapy.
    Salami et al.
    Science, 2017;355:1163

Product Datasheets

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