VH 032, phenol

Tocris Bioscience | Catalog # 6911

Hydroxyl functionalized VHL ligand
Tocris Bioscience

Key Product Details

Description

Hydroxyl functionalized VHL ligand

Alternative Names

(S,R,S)-AHPC-phenol
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Product Description

VH 032, phenol is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand with terminal hydroxyl ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for VH 032, phenol

Molecular Weight

488.60

Formula

C24H32N4O5S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S,4R)-1-((S)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

CAS Number

2244684-42-0

PubChem ID

142452655

InChI Key

CUHVZPHLQIBKHX-LVCYWYKZSA-N

SMILES

CC1=C(C2=CC=C(C(O)=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(C)=O)=O)O)=O)SC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 48.86 100
DMSO 48.86 100

Preparing Stock Solutions for VH 032, phenol

The following data is based on the product molecular weight 488.60.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.05 mL 10.23 mL 20.47 mL
5 mM 0.41 mL 2.05 mL 4.09 mL
10 mM 0.20 mL 1.02 mL 2.05 mL
50 mM 0.04 mL 0.20 mL 0.41 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for VH 032, phenol

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for VH 032, phenol

For research use only

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