VH 101, phenol New
Chemical Name: (2S,4R)-1-((S)-2-(1-Fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Biological ActivityFunctionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand with terminal hydroxyl ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage guidelines:This product is provided for use in onward chemistry. Suitable solvents can be used.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.
Maniaci et al.
Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast, and selective von Hippel-Lindau (VHL) based dual degrader probe of BRD9 and BRD7.
Zoppi et al.
Cereblon versus VHL: hijacking E3 ligases against each other using PROTACs.
Girardini et al.
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.
Farnaby et al.
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