VH 101, thiol

Tocris Bioscience | Catalog # 7884

Thiol functionalized VHL ligand
Tocris Bioscience

Key Product Details

Description

Thiol functionalized VHL ligand
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Product Description

VH 101, thiol is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand with terminal thiol ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications for VH 101, thiol

Molecular Weight

534.67

Formula

C25H31FN4O4S2

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

(2S,4R)-1-[(2R)-2-[[(1-Fluorocyclopropyl)carbonyl]amino]-3-methyl-3-sulfanyl-butanoyl]-4-hydroxy-N-[[4-(4-methylthiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

CAS Number

2358775-81-0

InChI Key

RCVHBJGYHDKFGZ-WSTZPKSXSA-N

SMILES

O=C(C1(CC1)F)N[C@@H](C(C)(S)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=CC=C(C4=C(N=CS4)C)C=C3)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for VH 101, thiol

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for VH 101, thiol

For research use only

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