VHF 543, amine

Tocris Bioscience | Catalog # 8075

DCAF1 WD40 ligand with terminal amine for onward chemistry
Tocris Bioscience

Key Product Details

Description

DCAF1 WD40 ligand with terminal amine for onward chemistry
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Product Description

VHF 543, amine is a potent ligand for the WD40 repeat domain (WDR) of DCAF1 (Kd = 31 nM measured by surface plasmon resonance). VHF 543, amine is supplied with a primary amine functional handle, for ready conjugation to a linker/target protein ligand.

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PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for VHF 543, amine

Molecular Weight

507.08

Formula

C28H35ClN6O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

1-(4-(4-((2-Aminoethyl)amino)-2-(1-(4-chlorophenyl)cyclohexyl)quinazolin-7-yl)piperazin-1-yl)ethan-1-one

CAS Number

3053860-67-3

PubChem ID

168069227

InChI Key

GGEKTDCCHNVLNE-UHFFFAOYSA-N

SMILES

NCCNC1=NC(C2(C3=CC=C(C=C3)Cl)CCCCC2)=NC4=CC(N5CCN(CC5)C(C)=O)=CC=C41

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.14 20

Preparing Stock Solutions for VHF 543, amine

The following data is based on the product molecular weight 507.08.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.86 mL 49.30 mL 98.60 mL
1 mM 1.97 mL 9.86 mL 19.72 mL
2 mM 0.99 mL 4.93 mL 9.86 mL
10 mM 0.20 mL 0.99 mL 1.97 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for VHF 543, amine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for VHF 543, amine

For research use only

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