Catalog Number: 0808
Alternate Names: (±)-γ-Vinyl GABA
Chemical Name: 4-Aminohexenoic acid
Biological Activity
Selective GABA-T (transaminase) inhibitor. Anticonvulsant.
Technical Data
  • M.Wt:
    129.16
  • Formula:
    C6H11NO2
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    60643-86-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Differential effect of gamma-vinyl GABA and valproate on GABA transaminase from cultured neurones and astrocytes.
    Larsson et al.
    Neuropharmacology, 1986;25:617
  2. Effects of vigabatrin (γ-vinyl GABA) on neurotransmission-related amino acids and on GABA and benzodiazepine receptor binding in rats.
    Halonen et al.
    Epilepsia, 1991;32:242
  3. Vigabatrin modulates benzodiazepine receptor activity in vivo: a positron emission tomography study in baboon.
    Schmid et al.
    J.Pharmacol.Exp.Ther., 1996;276:977
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Vigabatrin include:

1 Citations: Showing 1 - 1

  1. Glutamate uptake triggers transporter-mediated GABA release from astrocytes.
    Authors: Héja Et al.
    Stem Cells Dev 2009;4:e7153

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