VO-OHpic

Key Product Details

Product Description

VO-OHpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) (IC₅₀ = 35 nM). Displays selectivity for PTEN over cysteine-based phosphatases such as SopB, MTM, PTPβ and SAC (IC₅₀ values are 588 nM, 4.03, 57.5 and >10 μM respectively). Increases PIP₂ and PIP₃ levels; also increases Akt translocation in NIH/3T3 fibroblasts. Blocks the immunosuppressant activity of IDO-activated T_regs. Promotes antitumor inflammatory response in combination with immunotherapy and enhances anticancer chemotherapy in tumor-bearing mice.

Product Specifications for VO-OHpic

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VO-OHpic

The following data is based on the product molecular weight 361.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.77 mL	13.84 mL	27.69 mL
5 mM	0.55 mL	2.77 mL	5.54 mL
10 mM	0.28 mL	1.38 mL	2.77 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

• Sharma The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment. Sci.Adv. 2015 PMID: 26601142
• Rosivatz A small-molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem.Biol. 2006 PMID: 17240976

Product Documents for VO-OHpic