Chemical Name: 2-(2-Bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide
Biological ActivityKir4.1 potassium channel blocker (IC50 = 0.97 μM). Displays 10-fold selectivity for Kir4.1 over Kir4.1/5.1 concatemeric channels and >30-fold selectivity over Kir1.1, 2.1 and 2.2. Increases urine output and urinary Na+ and K+ excretion in volume-loaded rats.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery, characterization, and effects on renal fluid and electrolyte excretion of the Kir4.1 potassium channel pore blocker, VU0134992.
Kharade et al.
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