Home / Inward Rectifier Potassium Channel Blockers / VU 0134992

VU 0134992

6877 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6877/50
6877/10
Inward Rectifier Potassium Channel Blockers Small Molecule
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Description: Kir4.1 blocker

Chemical Name: 2-(2-Bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide

Purity: ≥98%

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Biological Activity

Kir4.1 potassium channel blocker (IC50 = 0.97 μM). Displays 10-fold selectivity for Kir4.1 over Kir4.1/5.1 concatemeric channels and >30-fold selectivity over Kir1.1, 2.1 and 2.2. Increases urine output and urinary Na+ and K+ excretion in volume-loaded rats.

Technical Data

M.Wt:
411.38
Formula:
C20H31BrN2O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
755002-90-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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