Potent, positive allosteric modulator/allosteric agonist at mGlu4
= 798 and 693 nM at human and rat mGlu4
receptors respectively). Active in in vivo
models of Parkinson's disease following i.c.v. administration. Sodium salt of VU 0155041
(Cat. No. 3248).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.
Niswender et al.