VU 0155041

  ( 3 citations )    
Product Datasheet
Catalog Number:3248
Chemical Name:cis-2-[[(3,5-Dichlorophenyl)amino]carbonyl]cyclohexanecarboxylic acid
Product Details
Citations (3)
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Reviews
Biological Activity
Potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively). Active in in vivo models of Parkinson's disease following i.c.v. administration. Also available as sodium salt (Cat. No. 3311).
Technical Data
  • M.Wt:
    316.18
  • Formula:
    C14H15Cl2NO3
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    1093757-42-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for VU 0155041 include:

3 Citations: Showing 1 - 3
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  1. Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (
    Authors: Jones Et al.
    J Med Chem  2011;54:7639
  2. Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges.
    Authors: Duvoisin Et al.
    Behav Brain Res  2011;221:50
  3. Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4).
    Authors: Williams Et al.
    Bioorg Med Chem Lett  2009;19:4967

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