Chemical Name: cis-2-[[(3,5-Dichlorophenyl)amino]carbonyl]cyclohexanecarboxylic acid
Biological ActivityPotent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively). Active in in vivo models of Parkinson's disease following i.c.v. administration. Also available as sodium salt (Cat. No. 3311).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.
Niswender et al.
Citations for VU 0155041
The citations listed below are publications that use Tocris products. Selected citations for VU 0155041 include:
3 Citations: Showing 1 - 3
Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (
Authors: Jones Et al.
J Med Chem 2011;54:7639
Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges.
Authors: Duvoisin Et al.
Behav Brain Res 2011;221:50
Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4).
Authors: Williams Et al.
Bioorg Med Chem Lett 2009;19:4967
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