VU 0240551

  ( 4 citations )    
Product Datasheet
Catalog Number:3888
Chemical Name:N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide
Product Details
Citations (4)
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Reviews
Biological Activity
Inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC50 = 560 nM for K+ uptake assay in KCC2-overexpressing cells). Exhibits selectivity over the Na-K-2Cl cotransporter, NKCCl. Also inhibits hERG and L-type Ca2+ channels.
Technical Data
  • M.Wt:
    342.43
  • Formula:
    C16H14N4OS2
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    893990-34-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for VU 0240551 include:

4 Citations: Showing 1 - 4
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  1. Enhancing K-Cl co-transport restores normal spinothalamic sensory coding in a neuropathic pain model.
    Authors: Lavertu Et al.
    Brain  2014;137:724
  2. Chloride extrusion enhancers as novel therapeutics for neurological diseases.
    Authors: Gagnon Et al.
    Nat Med  2013;19:1524
  3. GABA is excitatory in adult vasopressinergic neuroendocrine cells.
    Authors: Haam Et al.
    J Neurosci  2012;32:572
  4. Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis.
    Authors: Doyon Et al.
    Purinergic Signal  2011;7:e1002149

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