VU 0357017 hydrochloride

Tocris Bioscience | Catalog # 4295

Positive allosteric modulator of M1 receptors
Tocris Bioscience

Key Product Details

Description

Positive allosteric modulator of M1 receptors
View all mAChR M1 Modulators »

Product Description

VU 0357017 hydrochloride is a positive allosteric modulator of muscarinic M1 receptors (EC50 = 198 nM). Displays no activity at M2-M5 at concentrations up to 30 μM. Potentiates NMDA receptor currents in hippocampal neurons; activity reverses cognitive decifits in a rodent model of hippocampal-dependent memory. CNS penetrant.

Product Specifications for VU 0357017 hydrochloride

Molecular Weight

369.89

Formula

C18H27N3O3.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester hydrochloride

CAS Number

1135242-13-5

PubChem ID

25010775

InChI Key

XKJQVUIXSBOCPP-UHFFFAOYSA-N

SMILES

CC1=CC=CC=C1C(NCCNC2CCN(C(OCC)=O)CC2)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.25 25
DMSO 1.85 5

Preparing Stock Solutions for VU 0357017 hydrochloride

The following data is based on the product molecular weight 369.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 10.81 mL 54.07 mL 108.14 mL
1.25 mM 2.16 mL 10.81 mL 21.63 mL
2.5 mM 1.08 mL 5.41 mL 10.81 mL
12.5 mM 0.22 mL 1.08 mL 2.16 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for VU 0357017 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for VU 0357017 hydrochloride

For research use only

Citations for VU 0357017 hydrochloride

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