VU 0357017 hydrochloride

  ( 1 citations )    
Product Datasheet
Catalog Number:4295
Chemical Name:4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester hydrochloride
Product Details
Citations (1)
Supplemental Products
Reviews
Biological Activity
Positive allosteric modulator of muscarinic M1 receptors (EC50 = 198 nM). Displays no activity at M2-M5 at concentrations up to 30 μM. Potentiates NMDA receptor currents in hippocampal neurons; activity reverses cognitive decifits in a rodent model of hippocampal-dependent memory. CNS penetrant.
Technical Data
  • M.Wt:
    369.89
  • Formula:
    C18H27N3O3.HCl
  • Solubility:
    Soluble to 25 mM in water and to 5 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    1135242-13-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for VU 0357017 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress.
    Authors: Jadeja Et al.
    J Am Soc Nephrol  2016;6:405

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