Catalog Number: 4295
Chemical Name: 4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester hydrochloride
Biological Activity
Positive allosteric modulator of muscarinic M1 receptors (EC50 = 198 nM). Displays no activity at M2-M5 at concentrations up to 30 μM. Potentiates NMDA receptor currents in hippocampal neurons; activity reverses cognitive decifits in a rodent model of hippocampal-dependent memory. CNS penetrant.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in water and to 5 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) Lead. Part II. Development of potent and highly selective M1 PAM.
    Bridges et al.
    Bioorg.Med.Chem.Lett., 2010;20:1972
  2. Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M1 receptor function in the central nervous system.
    Lebois et al.
    ACS Chem.Neurosci., 2010;1:104

The citations listed below are publications that use Tocris products. Selected citations for VU 0357017 hydrochloride include:

Showing Results 1 - 1 of 1

  1. Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress.
    Authors: Jadeja Et al.
    J Am Soc Nephrol
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