VU 0357017 hydrochloride

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VU 0357017 hydrochloride | CAS No. 1135242-13-5 | mAChR M1 Modulators
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Description: Positive allosteric modulator of M1 receptors

Chemical Name: 4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester hydrochloride

Purity: ≥98%

Product Details
Citations (1)
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Reviews

Biological Activity

Positive allosteric modulator of muscarinic M1 receptors (EC50 = 198 nM). Displays no activity at M2-M5 at concentrations up to 30 μM. Potentiates NMDA receptor currents in hippocampal neurons; activity reverses cognitive decifits in a rodent model of hippocampal-dependent memory. CNS penetrant.

Technical Data

M.Wt:
369.89
Formula:
C18H27N3O3.HCl
Solubility:
Soluble to 25 mM in water and to 5 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1135242-13-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) Lead. Part II. Development of potent and highly selective M1 PAM.
    Bridges et al.
    Bioorg.Med.Chem.Lett., 2010;20:1972
  2. Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M1 receptor function in the central nervous system.
    Lebois et al.
    ACS Chem.Neurosci., 2010;1:104

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Citation for VU 0357017 hydrochloride

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