VU 0357017 hydrochloride
Chemical Name: 4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester hydrochloride
Biological ActivityPositive allosteric modulator of muscarinic M1 receptors (EC50 = 198 nM). Displays no activity at M2-M5 at concentrations up to 30 μM. Potentiates NMDA receptor currents in hippocampal neurons; activity reverses cognitive decifits in a rodent model of hippocampal-dependent memory. CNS penetrant.
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Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) Lead. Part II. Development of potent and highly selective M1 PAM.
Bridges et al.
Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M1 receptor function in the central nervous system.
Lebois et al.
ACS Chem.Neurosci., 2010;1:104
Citation for VU 0357017 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for VU 0357017 hydrochloride include:
1 Citation: Showing 1 - 1
Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress.
Authors: Jadeja Et al.
J Am Soc Nephrol 2016;6:405
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