Chemical Name: N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
Biological ActivityVU 0361737 is a selective positive allosteric modulator at mGlu4 receptors (EC50 values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors. Brain penetrant.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).
Engers et al.
Discovery, synthesis, and structure-activity relationship development of a series of N-(4-Acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu4) with CNS exposure in rats.
Engers et al.
Citation for VU 0361737
The citations listed below are publications that use Tocris products. Selected citations for VU 0361737 include:
1 Citation: Showing 1 - 1
Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (
Authors: Jones Et al.
J Med Chem 2011;54:7639
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