Potent and selective mGlu5
negative allosteric modulator (IC50
= 49 nM at human mGlu5
). Selective for mGlu5
over a panel of GPCRs and ion channels. Exhibits no significant nonspecific binding in rat brain homogenates in vitro
. Inhibits marble burying behavior in mice. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.
Felts et al.