Home / Group I mGluR Modulators / VU 0409106

VU 0409106

Catalog #: 5322 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5322/10
5322/50
VU 0409106 | CAS No. 1276617-62-9 | Group I mGluR Modulators
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Description: Potent and selective negative allosteric modulator of mGlu5 receptors

Chemical Name: 3-Fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)benzamide

Purity: ≥98%

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Biological Activity

VU 0409106 is a potent and selective mGlu5 negative allosteric modulator (IC50 = 49 nM at human mGlu5). Selective for mGlu5 over a panel of GPCRs and ion channels. Exhibits no significant nonspecific binding in rat brain homogenates in vitro. Inhibits marble burying behavior in mice. Brain penetrant.

Technical Data

M.Wt:
330.34
Formula:
C15H11FN4O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1276617-62-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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