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VU 0546110

Catalog #: 7956 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7956/50
7956/10

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VU 0546110 | CAS No. 1421523-00-3 | Non-selective/Other Potassium Channel Blockers
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Description: Selective SLO3 potassium channel inhibitor

Chemical Name: 1-[4-[[(4-Methoxyphenyl)thio]methyl]-1-piperidinyl]-2-[4-[(1-methylethyl)sulfonyl]phenyl]ethanone

Purity: ≥98%

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Biological Activity

VU 0546110 is a selective inhibitor of the sperm-specific potassium channel SLO3 (IC50 = 64 μM). It shows 40-fold selectivity over SLO1. It completely blocks heterologous SLO3 currents and endogenous K+ currents. VU 0546110 inhibits sperm hyperpolarisation and prevents its hyperactivated mobility.

Technical Data

M.Wt:
461.64
Formula:
C24H31NO4S2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1421523-00-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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