VU 0546110

Key Product Details

Product Description

VU 0546110 is a selective inhibitor of the sperm-specific potassium channel SLO3 (IC₅₀ = 64 μM). It shows 40-fold selectivity over SLO1. It completely blocks heterologous SLO3 currents and endogenous K⁺ currents. VU 0546110 inhibits sperm hyperpolarisation and prevents its hyperactivated mobility.

Product Specifications for VU 0546110

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VU 0546110

The following data is based on the product molecular weight 461.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.17 mL	10.83 mL	21.66 mL
5 mM	0.43 mL	2.17 mL	4.33 mL
10 mM	0.22 mL	1.08 mL	2.17 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Lyon A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function. Proc.Natl.Acad.Sci.U.S.A. 2023 PMID: 36649421

Product Documents for VU 0546110