Selective allosteric potentiator of M4
acetylcholine receptors (EC50
values are 33 and 0.7 nM for ACh in the absence and presence of VU10010�respectively). Binds to an allosteric site on the receptor increasing affinity for ACh and coupling to G-proteins.
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An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission.
Shirey et al.
The citations listed below are publications that use Tocris products. Selected citations for VU 10010 include:
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