Chemical Name: 3-Amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
Biological ActivityVU 10010 is a selective allosteric potentiator of M4 acetylcholine receptors (EC50 values are 33 and 0.7 nM for ACh in the absence and presence of VU10010 respectively). Binds to an allosteric site on the receptor increasing affinity for ACh and coupling to G-proteins.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission.
Shirey et al.
Citation for VU 10010
The citations listed below are publications that use Tocris products. Selected citations for VU 10010 include:
1 Citation: Showing 1 - 1
Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation.
Authors: Bell Et al.
PLoS One 2015;9:115
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