Catalog Number: 3141
Chemical Name: 3-Amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
Biological Activity
Selective allosteric potentiator of M4 acetylcholine receptors (EC50 values are 33 and 0.7 nM for ACh in the absence and presence of VU10010�respectively). Binds to an allosteric site on the receptor increasing affinity for ACh and coupling to G-proteins.
Technical Data
  • M.Wt:
    345.85
  • Formula:
    C17H16ClN3OS
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    633283-39-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission.
    Shirey et al.
    Nat.Chem.Biol., 2008;4:42
Citations:

The citations listed below are publications that use Tocris products. Selected citations for VU 10010 include:

1 Citations: Showing 1 - 1

  1. Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation.
    Authors: Bell Et al.
    PLoS One 2015;9:115

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