VU 152100

Key Product Details

Product Description

VU 152100 is a selective positive allosteric modulator of M₄ muscarinic acetylcholine receptors (mAChRs) (EC₅₀ = 380 nM). Induces 21-fold shift in ACh potency at M₄ receptor. Displays no activity at other mAChR subtypes.

Product Specifications for VU 152100

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VU 152100

The following data is based on the product molecular weight 341.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.86 mL	29.29 mL	58.58 mL
2.5 mM	1.17 mL	5.86 mL	11.72 mL
5 mM	0.59 mL	2.93 mL	5.86 mL
25 mM	0.12 mL	0.59 mL	1.17 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Brady Centrally active allosteric potentiators of the M₄ muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J.Pharmacol.Exp.Ther. 2008 PMID: 18772318

Product Documents for VU 152100