Selective positive allosteric modulator of M4
muscarinic acetylcholine receptors (mAChRs) (EC50
= 380 nM). Induces 21-fold shift in ACh potency at M4
receptor. Displays no activity at other mAChR subtypes.
Soluble to 50 mM in DMSO
Store at RT
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All Tocris products are intended for laboratory research use only.
Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats.
Brady et al.