Metabotropic glutamate receptor 5 (mGlu5
) positive allosteric modulator (EC50
= 9.6 nM, Ki
= 156 nM at rat mGlu5
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Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes.
de Paulis et al.