VU 1545

Key Product Details

Product Description

VU 1545 is a metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (EC₅₀ = 9.6 nM, K_i = 156 nM at rat mGlu₅).

Product Specifications for VU 1545

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VU 1545

The following data is based on the product molecular weight 402.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.49 mL	12.43 mL	24.85 mL
5 mM	0.50 mL	2.49 mL	4.97 mL
10 mM	0.25 mL	1.24 mL	2.49 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• de Paulis Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes. J.Med.Chem. 2006 PMID: 16722652

Product Documents for VU 1545