VU 590 dihydrochloride
Chemical Name: 7,13-Bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane dihydrochloride
Biological ActivityInhibits the renal outer medullary potassium channel (Kir1.1, ROMK) (IC50 = 294 nM). Also inhibits the inward retifying K+ channel Kir7.1; displays no effect upon Kir2.1 or Kir4.1. Acts as an intracellular Kir1.1 channel pore blocker.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1.
Lewis et al.
Citations for VU 590 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for VU 590 dihydrochloride include:
2 Citations: Showing 1 - 2
The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis.
Authors: Yin Et al.
Nat Commun 2018;9:2815
Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel.
Authors: Bhave Et al.
Mol Pharmacol 2011;79:42
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Reviews for VU 590 dihydrochloride
Average Rating: 5 (Based on 1 Review)
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Vu 590 works beautifully on Inwardly Rectifying Potassium Channels but not on all subfamilies. The blocking effect showed by VU 590 is variable on the different classes of Kir channels. Overall acts as a great measure for comparing blocking action.