VU 590 dihydrochloride

Catalog # Availability Size / Price Qty
3891/10
3891/50
VU 590 dihydrochloride | CAS No. 1783987-83-6 | Inward Rectifier Potassium Channel Blockers
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Description: Inhibitor of Kir1.1 (ROMK) and Kir7.1

Chemical Name: 7,13-Bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane dihydrochloride

Purity: ≥97%

Product Details
Citations (2)
Reviews (1)

Biological Activity

Inhibits the renal outer medullary potassium channel (Kir1.1, ROMK) (IC50 = 294 nM). Also inhibits the inward retifying K+ channel Kir7.1; displays no effect upon Kir2.1 or Kir4.1. Acts as an intracellular Kir1.1 channel pore blocker.

Technical Data

M.Wt:
561.46
Formula:
C24H32N4O7.2HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
1783987-83-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for VU 590 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for VU 590 dihydrochloride include:

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Reviews for VU 590 dihydrochloride

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Vu 590 works beautifully on Inwardly Rectifying Potassium Channels but not on all subfamilies
By Anonymous on 10/31/2018
Species: Human

Vu 590 works beautifully on Inwardly Rectifying Potassium Channels but not on all subfamilies. The blocking effect showed by VU 590 is variable on the different classes of Kir channels. Overall acts as a great measure for comparing blocking action.


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