Inhibits the renal outer medullary potassium channel (Kir
1.1, ROMK) (IC50
= 294 nM). Also inhibits the inward retifying K+
7.1; displays no effect upon Kir
2.1 or Kir
4.1. Acts as an intracellular Kir
1.1 channel pore blocker.
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High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1.
Lewis et al.