Biological ActivityVU 6001966 is a potent and selective mGlu2 negative allosteric modulator (IC50 = 78 nM). Exhibits > 350-fold selectivity for mGlu2 over mGlu3. Also exhibits selectivity over other mGluRs and a panel of GPCRs, ion channels and transporters. CNS penetrant.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Design and synthesis of mGlu2 NAMs with improved potency and CNS penetration based on a truncated picolinamide core.
Bollinger et al.
ACS Med.Chem.Lett., 2017;8:919
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for VU 6001966
There are currently no reviews for this product. Be the first to review VU 6001966 and earn rewards!
Have you used VU 6001966?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image