VU 6015929

Key Product Details

Product Description

VU 6015929 is a potent and selective discoidin domain receptor 1/2 (DDR1/2) inhibitor (IC₅₀ = 4.67 nM and 7.39 nM for DDR1 and DDR2, respectively). VU 6015929 blocks collagen-induced DDR1 activation and collagen-IV production in HEK293 cells.

Product Specifications for VU 6015929

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VU 6015929

The following data is based on the product molecular weight 485.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.06 mL	10.30 mL	20.60 mL
5 mM	0.41 mL	2.06 mL	4.12 mL
10 mM	0.21 mL	1.03 mL	2.06 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Jeffries Discovery of VU6015929: a selective discoidin domain receptor 1/2 (DDR1/2) inhibitor to explore the role of DDR1 in antifibrotic therapy. ACS Med.Chem.Lett. 2019 PMID: 31938459
• Sun Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion. Nature 2021 PMID: 34732895

Product Documents for VU 6015929