VUF 11207 fumarate
Chemical Name: N-[(2E)-3-(2-Fluorophenyl)-2-methyl-2-propen-1-yl]-3,4,5-trimethoxy-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]benzamide fumarate
Biological ActivityVUF 11207 fumarate is a potent ACKR3 (CXCR7) chemokine receptor agonist (EC50 = 1.6 nM). Induces recruitment of β-arrestin to CXCR7 in HEK293-CXCR7 cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists.
Wijtmans et al.
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