Potent ACKR3 (CXCR7) chemokine receptor agonist (EC50
= 1.6 nM). Induces recruitment of β
-arrestin to CXCR7 in HEK293-CXCR7 cells.
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Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists.
Wijtmans et al.