Catalog Number: 1359
Chemical Name: N-(2-Methoxyphenyl)-N'-[2-(3-pyrindinyl)-4-quinazolinyl]-urea
Biological Activity
Potent, selective, competitive antagonist for the human adenosine A3 receptor (Ki = 4 nM). Displays ≥ 2500-fold selectivity over A1 and A2A receptors.
Technical Data
  • M.Wt:
    371.39
  • Formula:
    C21H17N5O2
  • Solubility:
    Soluble to 4 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    280570-45-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. New potent and selective human adenosine A3 receptor antagonists.
    Baraldi and Borea
    TiPS, 2000;21:456
  2. Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A3 receptor.
    van Muijlwijk-Koezen et al.
    J.Med.Chem., 2000;43:2227
Citations:

The citations listed below are publications that use Tocris products. Selected citations for VUF 5574 include:

2 Citations: Showing 1 - 2
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  1. IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors.
    Authors: Hua Et al.
    PLoS One 2011;6:e24947
  2. A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro.
    Authors: Pugliese Et al.
    Br J Pharmacol 2006;147:524

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