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VUF 5574

Catalog #: 1359
2 Citations Datasheet / COA / SDS

Discontinued Product

1359 has been discontinued.
View all Adenosine A3 Receptor Antagonists products.
VUF 5574 | CAS No. 280570-45-8 | Adenosine A3 Receptor Antagonists
1 Image
Description: Potent, selective hA3 antagonist

Chemical Name: N-(2-Methoxyphenyl)-N'-[2-(3-pyrindinyl)-4-quinazolinyl]-urea

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

VUF 5574 is a potent, selective, competitive antagonist for the human adenosine A3 receptor (Ki = 4 nM). Displays ≥ 2500-fold selectivity over A1 and A2A receptors.

Technical Data

M.Wt:
371.39
Formula:
C21H17N5O2
Solubility:
Soluble to 4 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
280570-45-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. New potent and selective human adenosine A3 receptor antagonists.
    Baraldi and Borea
    TiPS, 2000;21:456
  2. Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A3 receptor.
    van Muijlwijk-Koezen et al.
    J.Med.Chem., 2000;43:2227

Product Datasheets

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Citations for VUF 5574

The citations listed below are publications that use Tocris products. Selected citations for VUF 5574 include:

2 Citations: Showing 1 - 2

  1. IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors.
    Authors: Hua Et al.
    PLoS One  2011;6:e24947
  2. A3 adenosine receptor antagonists delay irreversible synaptic failure caused by oxygen and glucose deprivation in the rat CA1 hippocampus in vitro.
    Authors: Pugliese Et al.
    Br J Pharmacol  2006;147:524

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