Catalog Number: 2493
Chemical Name: 4-[3-(1H-Imidazol-4-yl)propyl]piperidine dihydrobromide
Biological Activity
Potent histamine H3 receptor silent antagonist (pKi = 8.35).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H3 receptor agonist.
    Kitbunnadaj et al.
    J.Med.Chem., 2004;47:2414
  2. The histamine H3 receptor: from gene cloning to H3 receptor drugs.
    Leurs et al.
    Nat.Rev.Drug Discov., 2005;4:107
  3. Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway.
    Moreno-Delgado et al.
    Neuropharmacology, 2006;51:517
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