VUF 5681 dihydrobromide

Key Product Details

Product Description

VUF 5681 dihydrobromide is a potent histamine H₃ receptor silent antagonist (pK_i = 8.35).

Product Specifications for VUF 5681 dihydrobromide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VUF 5681 dihydrobromide

The following data is based on the product molecular weight 355.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.82 mL	14.08 mL	28.16 mL
5 mM	0.56 mL	2.82 mL	5.63 mL
10 mM	0.28 mL	1.41 mL	2.82 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Leurs The histamine H3 receptor: from gene cloning to H₃ receptor drugs. Nat.Rev.Drug Discov. 2005 PMID: 15665857
• Moreno-Delgado Constitutive activity of H₃ autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. Neuropharmacology 2006 PMID: 16769092
• Kitbunnadaj Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H₃ receptor agonist. J.Med.Chem. 2004 PMID: 15115383

Product Documents for VUF 5681 dihydrobromide