VUF 5681 dihydrobromide
Chemical Name: 4-[3-(1H-Imidazol-4-yl)propyl]piperidine dihydrobromide
Biological ActivityPotent histamine H3 receptor silent antagonist (pKi = 8.35).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H3 receptor agonist.
Kitbunnadaj et al.
The histamine H3 receptor: from gene cloning to H3 receptor drugs.
Leurs et al.
Nat.Rev.Drug Discov., 2005;4:107
Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway.
Moreno-Delgado et al.
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