Chemical Name: N-[[4-(Dimethylamino)phenyl]methyl]-1,2,3,4-tetrahydro-7-methoxy-N-[4-(1-methylethyl)phenyl]-1-naphthalenecarboxamide hydrochloride
Biological ActivityHigh affinity C5a receptor antagonist (Ki = 2.2 nM). Inhibits C5a-induced generation of reactive superoxide species, chemotaxis and intracellular Ca2+ mobilization in human neutrophils (IC50 values are 1.6, 2.7 and 3.1 nM, respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Identification of a potent and orally active non-peptide C5a receptor antagonist.
Sumichika et al.
Function, structure and therapeutic potential of complement C5a receptors.
Monk et al.
Autocrine effects of tumor-derived complement.
Cho et al.
Cell Rep., 2014;6:1085
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