W 54011

Catalog # Availability Size / Price Qty
W 54011 | CAS No. 405098-33-1 | Complement Signaling inhibitors
1 Image
Description: High affinity C5a receptor antagonist

Chemical Name: N-[[4-(Dimethylamino)phenyl]methyl]-1,2,3,4-tetrahydro-7-methoxy-N-[4-(1-methylethyl)phenyl]-1-naphthalenecarboxamide hydrochloride

Purity: ≥98%

Product Details
Citations (2)
Supplemental Products

Biological Activity

W 54011 is a high affinity C5a receptor antagonist (Ki = 2.2 nM). Inhibits C5a-induced generation of reactive superoxide species, chemotaxis and intracellular Ca2+ mobilization in human neutrophils (IC50 values are 1.6, 2.7 and 3.1 nM, respectively).

Technical Data

Soluble to 50 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of a potent and orally active non-peptide C5a receptor antagonist.
    Sumichika et al.
    J.Biol.Chem., 2002;277:49403
  2. Function, structure and therapeutic potential of complement C5a receptors.
    Monk et al.
    Br.J.Pharmacol., 2007;152:429
  3. Autocrine effects of tumor-derived complement.
    Cho et al.
    Cell Rep., 2014;6:1085

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Citations for W 54011

The citations listed below are publications that use Tocris products. Selected citations for W 54011 include:

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