Chemical Name: N-[[4-(Dimethylamino)phenyl]methyl]-1,2,3,4-tetrahydro-7-methoxy-N-[4-(1-methylethyl)phenyl]-1-naphthalenecarboxamide hydrochloride
Biological ActivityHigh affinity C5a receptor antagonist (K i = 2.2 nM). Inhibits C5a-induced generation of reactive superoxide species, chemotaxis and intracellular Ca 2+ mobilization in human neutrophils (IC 50 values are 1.6, 2.7 and 3.1 nM, respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of a potent and orally active non-peptide C5a receptor antagonist.
Sumichika et al.
Function, structure and therapeutic potential of complement C5a receptors.
Monk et al.
Autocrine effects of tumor-derived complement.
Cho et al.
Cell Rep., 2014;6:1085
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