Chemical Name: N-[[4-(Dimethylamino)phenyl]methyl]-1,2,3,4-tetrahydro-7-methoxy-N-[4-(1-methylethyl)phenyl]-1-naphthalenecarboxamide hydrochloride
Biological ActivityW 54011 is a high affinity C5a receptor antagonist (Ki = 2.2 nM). Inhibits C5a-induced generation of reactive superoxide species, chemotaxis and intracellular Ca2+ mobilization in human neutrophils (IC50 values are 1.6, 2.7 and 3.1 nM, respectively).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of a potent and orally active non-peptide C5a receptor antagonist.
Sumichika et al.
Function, structure and therapeutic potential of complement C5a receptors.
Monk et al.
Autocrine effects of tumor-derived complement.
Cho et al.
Cell Rep., 2014;6:1085
Citations for W 54011
The citations listed below are publications that use Tocris products. Selected citations for W 54011 include:
2 Citations: Showing 1 - 2
Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors.
Authors: Trent M Et al.
Mol Cell 2021;81:4605-4621.e11
Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21.
Authors: Sahu Et al.
Cell Rep 2019;28:2567
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