W-7 hydrochloride

Tocris Bioscience | Catalog # 0369

Calmodulin antagonist. Inhibits myosin light chain kinase
Tocris Bioscience

Key Product Details

Description

Calmodulin antagonist. Inhibits myosin light chain kinase
View all Calcium Binding Protein Modulator Antagonists »

Product Description

W-7 hydrochloride is a calmodulin antagonist. Inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 μM) and myosin light chain kinase (IC50 = 51 μM). Induces shedding of platelet receptors GPVI, GPV and GPIbα.

Product Specifications for W-7 hydrochloride

Molecular Weight

377.33

Formula

C16H21ClN2O2S.HCl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride

CAS Number

61714-27-0

PubChem ID

124887

InChI Key

OMMOSRLIFSCDBL-UHFFFAOYSA-N

SMILES

Cl.NCCCCCCNS(=O)(=O)C1=CC=CC2=C(Cl)C=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 1.89 5 with gentle warming
DMSO 37.73 100

Preparing Stock Solutions for W-7 hydrochloride

The following data is based on the product molecular weight 377.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.25 mL 26.50 mL
5 mM 0.53 mL 2.65 mL 5.30 mL
10 mM 0.27 mL 1.33 mL 2.65 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

Calculators

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Product Documents for W-7 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for W-7 hydrochloride

For research use only

Citations for W-7 hydrochloride

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  • PN and PH cells were treated with W-7 (catalog no. 0369) and W-13 (catalog no. 0361) purchased from Tocris.
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: PN and PH cells
    Verified Customer | Posted 11/17/2019
    PN and PH cells were treated with W-7 (catalog no. 0369) and W-13 (catalog no. 0361) purchased from Tocris.
    W-7 hydrochloride 0369

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