Chemical Name: N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride
Biological ActivityCalmodulin antagonist. Inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 μM) and myosin light chain kinase (IC50 = 51 μM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase.
Itoh and Hidaka
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation.
Hidaka et al.
Hydrophobic regions function in calmodulin-enzyme(s) interactions.
Tanaka and Hidaka
Divergent pharmacological effects of three calmodulin antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W 7), chlorprom. and calmidazolium, on isometric tension development and myosin light chain phosphorylation in intact bovine trachea
Asano et al.
Citations for W-7 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for W-7 hydrochloride include:
15 Citations: Showing 1 - 10
P38 inhibition reverses TGFβ1 and TNFα-induced contraction in a model of proliferative vitreoretinopathy.
Authors: Schiff Et al.
Commun Biol 2019;2:162
The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea.
Authors: Haag Et al.
Cell Rep 2018;24:2418
Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca(2+) in knock-out mouse models of polycystic kidney disease.
Authors: Yanda Et al.
J Biol Chem 2017;292:17897
Voltage Dependence of a Neuromodulator-Activated Ionic Current.
Authors: Gray and Golowasch
Protein kinase G-regulated production of H2S governs oxygen sensing.
Authors: Yuan Et al.
Sci Signal 2015;8:ra37
Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP.
Authors: Araki Et al.
J Neurosci 2015;85:173
Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation.
Authors: Bonnefond Et al.
J Biol Chem 2015;20:535
The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin.
Authors: Hou Et al.
Dimerisation of the Drosophila odorant coreceptor Orco.
Authors: Mukunda Et al.
Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition.
Authors: Chang Et al.
Psychopharmacology (Berl) 2013;34:1096
The calcium signaling pathway regulates leydig cell steroidogenesis through a transcriptional cascade involving the nuclear receptor NR4A1 and the steroidogenic acute regulatory protein.
Authors: Abdou Et al.
Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways.
Authors: Midkiff Et al.
PLoS One 2011;6:e25395
Phospholipase C, Ca2+, and calmodulin signaling are required for 5-HT2A receptor-mediated transamidation of Rac1 by transglutaminase.
Authors: Dai Et al.
Front Cell Neurosci 2011;213:403
Dihydrotestosterone stimulates aldosterone secretion by H295R human adrenocortical cells.
Authors: Yanes and Romero
Mol Cell Endocrinol 2009;303:50
Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release.
Authors: Long Et al.
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Reviews for W-7 hydrochloride
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PN and PH cells were treated with W-7 (catalog no. 0369) and W-13(catalog no. 0361) purchased from Tocris.