W-7 hydrochloride

  ( 11 citations )    
Product Datasheet
Catalog Number:0369
Chemical Name:N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride
Product Details
Citations (11)
Reviews
Biological Activity
Calmodulin antagonist. Inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 μM) and myosin light chain kinase (IC50 = 51 μM).
Technical Data
  • M.Wt:
    377.33
  • Formula:
    C16H21ClN2O2S.HCl
  • Solubility:
    Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    61714-27-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for W-7 hydrochloride include:

11 Citations: Showing 1 - 10
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  1. Voltage Dependence of a Neuromodulator-Activated Ionic Current.
    Authors: Gray and Golowasch
    Eneuro  2016;3
  2. Protein kinase G-regulated production of H2S governs oxygen sensing.
    Authors: Yuan Et al.
    Sci Signal  2015;8:ra37
  3. Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP.
    Authors: Araki Et al.
    J Neurosci  2015;85:173
  4. Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation.
    Authors: Bonnefond Et al.
    J Biol Chem  2015;20:535
  5. The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin.
    Authors: Hou Et al.
    Apoptosis  2015;13:e1002233
  6. Dimerisation of the Drosophila odorant coreceptor Orco.
    Authors: Mukunda Et al.
    Neuron  2014;8:261
  7. Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition.
    Authors: Chang Et al.
    Psychopharmacology (Berl)  2013;34:1096
  8. Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways.
    Authors: Midkiff Et al.
    PLoS One  2011;6:e25395
  9. Phospholipase C, Ca2+, and calmodulin signaling are required for 5-HT2A receptor-mediated transamidation of Rac1 by transglutaminase.
    Authors: Dai Et al.
    Front Cell Neurosci  2011;213:403
  10. Dihydrotestosterone stimulates aldosterone secretion by H295R human adrenocortical cells.
    Authors: Yanes and Romero
    Mol Cell Endocrinol  2009;303:50
  11. Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release.
    Authors: Long Et al.
    Carcinogenesis  2009;284:8726
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