Catalog Number: 0369
Chemical Name: N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride
Biological Activity
Calmodulin antagonist. Inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 μM) and myosin light chain kinase (IC50 = 51 μM).
Technical Data
  • M.Wt:
    377.33
  • Formula:
    C16H21ClN2O2S.HCl
  • Solubility:
    Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    61714-27-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Divergent pharmacological effects of three calmodulin antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W 7), chlorpromazine and calmidazolium, on isometric tension development and myosin light chain phosphorylation in intact bovine trachea
    Asano et al.
    J.Pharmacol.Exp.Ther., 1989;251:764
  2. N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation.
    Hidaka et al.
    Proc.Natl.Acad.Sci.U.S.A., 1981;78:4354
  3. Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase.
    Itoh and Hidaka
    J.Biochem., 1984;96:1721
  4. Hydrophobic regions function in calmodulin-enzyme(s) interactions.
    Tanaka and Hidaka
    J.Biol.Chem., 1980;255:11078
Citations:

The citations listed below are publications that use Tocris products. Selected citations for W-7 hydrochloride include:

10 Citations: Showing 1 - 10
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  1. Protein kinase G-regulated production of H2S governs oxygen sensing.
    Authors: Yuan Et al.
    Sci Signal 2015;8:ra37
  2. Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP.
    Authors: Araki Et al.
    J Neurosci 2015;85:173
  3. Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation.
    Authors: Bonnefond Et al.
    J Biol Chem 2015;20:535
  4. The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin.
    Authors: Hou Et al.
    Apoptosis 2015;13:e1002233
  5. Dimerisation of the Drosophila odorant coreceptor Orco.
    Authors: Mukunda Et al.
    Neuron 2014;8:261
  6. Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition.
    Authors: Chang Et al.
    Psychopharmacology (Berl) 2013;34:1096
  7. Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways.
    Authors: Midkiff Et al.
    PLoS One 2011;6:e25395
  8. Phospholipase C, Ca2+, and calmodulin signaling are required for 5-HT2A receptor-mediated transamidation of Rac1 by transglutaminase.
    Authors: Dai Et al.
    Front Cell Neurosci 2011;213:403
  9. Dihydrotestosterone stimulates aldosterone secretion by H295R human adrenocortical cells.
    Authors: Yanes and Romero
    Mol Cell Endocrinol 2009;303:50
  10. Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release.
    Authors: Long Et al.
    Carcinogenesis 2009;284:8726

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