W-7 hydrochloride

Catalog # Availability Size / Price Qty
W-7 hydrochloride | CAS No. 61714-27-0 | Calcium Binding Protein Modulator Antagonists
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Description: Calmodulin antagonist. Inhibits myosin light chain kinase

Chemical Name: N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride

Purity: ≥98%

Product Details
Citations (16)

Biological Activity

W-7 hydrochloride is a calmodulin antagonist. Inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 μM) and myosin light chain kinase (IC50 = 51 μM).

Technical Data

Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for W-7 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for W-7 hydrochloride include:

16 Citations: Showing 1 - 10

  1. Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2.
    Authors: Lopez Et al.
    Neuron  2022;110:2283
  2. P38 inhibition reverses TGFβ1 and TNFα-induced contraction in a model of proliferative vitreoretinopathy.
    Authors: Schiff Et al.
    Commun Biol  2019;2:162
  3. The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea.
    Authors: Haag Et al.
    Cell Rep  2018;24:2418
  4. Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca(2+) in knock-out mouse models of polycystic kidney disease.
    Authors: Yanda Et al.
    J Biol Chem  2017;292:17897
  5. Voltage Dependence of a Neuromodulator-Activated Ionic Current.
    Authors: Gray and Golowasch
    Eneuro  2016;3
  6. Protein kinase G-regulated production of H2S governs oxygen sensing.
    Authors: Yuan Et al.
    Sci Signal  2015;8:ra37
  7. Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP.
    Authors: Araki Et al.
    J Neurosci  2015;85:173
  8. Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation.
    Authors: Bonnefond Et al.
    J Biol Chem  2015;20:535
  9. The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin.
    Authors: Hou Et al.
    Apoptosis  2015;13:e1002233
  10. Dimerisation of the Drosophila odorant coreceptor Orco.
    Authors: Mukunda Et al.
    Neuron  2014;8:261


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