Catalog Number: 1801
Chemical Name: 8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride
Biological Activity
Potent and selective 5-HT2C receptor agonist (Ki = 4 nM; EC50 = 12 nM). Antidepressant following systemic administration in vivo.
Technical Data
  • M.Wt:
    308.59
  • Formula:
    C11H11Cl2N3O.HCl
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    276695-22-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive
    Jensen et al.
    J.Med.Chem, 2013;56:1211
  2. Antidepressant-like behavioral effects mediated by 5-hydroxytryptamine2C receptors.
    Cryan and Lucki
    J.Pharmacol.Exp.Ther., 2000;295:1120
  3. Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines.
    Welmaker et al.
    Bioorg.Med.Chem.Lett., 2000;10:1991
Citations:

The citations listed below are publications that use Tocris products. Selected citations for WAY 161503 hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells.
    Authors: Hirono
    Neuropharmacology 2017;118:79
  2. 5-HT2C receptor agonist anorectic efficacy potentiated by 5-HT1B receptor agonist coapplication: an effect mediated via increased proportion of pro-opiomelanocortin neurons activated.
    Authors: Doslikova Et al.
    J Neurosci 2013;33:9800

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