WAY 161503 hydrochloride

Name: WAY 161503 hydrochloride
Brand: Tocris Bioscience
SKU: 1801
Price: 866 USD
Availability: InStock

Tocris Bioscience | Catalog # 1801

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Citations (14)

Product Documents

Potent and selective 5-HT2C agonist

Product Description
Product Specifications
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Potent and selective 5-HT2C agonist

View all 5-HT2C Receptor Agonists »

Product Description

WAY 161503 hydrochloride is a potent and selective 5-HT_2C receptor agonist (K_i = 4 nM; EC₅₀ = 12 nM). Shows approximately 2-fold selectivity for 5HT_2C over 5HT_2A in HEK293 cell lines (EC₅₀= 7.3 nM and 12 nM, respectively). Antidepressant following systemic administration in vivo.

Product Specifications for WAY 161503 hydrochloride

Molecular Weight

308.59

Formula

C₁₁H₁₁Cl₂N₃O.HCl

Storage

Desiccate at RT

Purity

≥99% (HPLC)

Chemical Name

8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride

CAS Number

276695-22-8

PubChem ID

21976692

InChI Key

YPNWSZJDAKOUAW-UHFFFAOYSA-N

SMILES

Cl.ClC1=CC2=C(C=C1Cl)N1CCNCC1C(=O)N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

Welmaker Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines. Bioorg.Med.Chem.Lett. 2000 PMID: 10987434
Jensen Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem. 2013 PMID: 23301527
Cryan and Lucki Antidepressant-like behavioral effects mediated by 5-hydroxytryptamine_2C receptors. J.Pharmacol.Exp.Ther. 2000 PMID: 11082448

Product Documents for WAY 161503 hydrochloride

Certificate of Analysis

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Product Specific Notices for WAY 161503 hydrochloride

For research use only

Related Research Areas

The Serotonergic System in Alzheimer's Disease

Citations for WAY 161503 hydrochloride

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