WAY 161503 hydrochloride
Chemical Name: 8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride
Biological ActivityWAY 161503 hydrochloride is a potent and selective 5-HT2C receptor agonist (Ki = 4 nM; EC50 = 12 nM). Antidepressant following systemic administration in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Antidepressant-like behavioral effects mediated by 5-hydroxytryptamine2C receptors.
Cryan and Lucki
Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines.
Welmaker et al.
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive
Jensen et al.
Citations for WAY 161503 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for WAY 161503 hydrochloride include:
4 Citations: Showing 1 - 4
Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells.
5-HT2C receptor agonist anorectic efficacy potentiated by 5-HT1B receptor agonist coapplication: an effect mediated via increased proportion of pro-opiomelanocortin neurons activated.
Authors: Doslikova Et al.
J Neurosci 2013;33:9800
Deconstructing antiobesity compound action: requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects.
Authors: Banas Et al.
Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat.
Br J Pharmacol 2008;155:343
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