High affinity, selective 5-HT6
= 7.3 nM at the human 5-HT6
receptor). Elevates cortical GABA levels in vivo
in rat frontal cortex. Exhibits antidepressant and anxiolytic-like effects.
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Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466.
Schechter et al.
Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats.
Carr et al.