Catalog Number: 3904
Chemical Name: 3-[(-3-Fluorophenyl)sulfonyl]-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-1-ethanamine dihydrochloride
Biological Activity
High affinity, selective 5-HT6 agonist (EC50 = 7.3 nM at the human 5-HT6 receptor). Elevates cortical GABA levels in vivo in rat frontal cortex. Exhibits antidepressant and anxiolytic-like effects.
Technical Data
  • M.Wt:
    420.33
  • Formula:
    C17H18FN3O2S.2HCl
  • Solubility:
    Soluble to 80 mM in water and to 80 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    1207064-61-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466.
    Schechter et al.
    Neuropsychopharmacol, 2008;33:1323
  2. Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats.
    Carr et al.
    Psychopharmacol.(Berl.), 2010;213:49

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