WAY 316606 hydrochloride: R&D Systems
Catalog Number: 4767
Chemical Name: 5-(Phenylsulfonyl)-N-4-piperidinyl-2-(trifluoromethyl)benzene sulfonamide hydrochloride
Biological Activity
Secreted Frizzled-Related Protein-1 (sFRP-1) inhibitor (IC50 = 0.65 μM); prevents sFRP-1 from interacting with Wnt and thus increases Wnt signaling. Increases total bone area in a murine calvarial organ culture assay.
Technical Data
  • M.Wt:
    484.94
  • Formula:
    C18H19F3N2O4S2.HCl
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II.
    Moore et al.
    Bioorg.Med.Chem., 2010;18:190
  2. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides.
    Moore et al.
    J.Med.Chem., 2009;52:105
  3. A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation.
    Bodine et al.
    Bone, 2009;44:1063

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