WDR5 0103

Tocris Bioscience | Catalog # 5323

WDR5 antagonist
Tocris Bioscience

Key Product Details

Description

WDR5 antagonist
View all Additional Lysine Methyltransferase Compounds »

Product Description

WDR5 0103 is a WD repeat-containing protein 5 (WDR5) antagonist (Kd = 450 nM). Disrupts WDR5 interaction with MLL and inhibits MLL core complex methyltransferase activity in vitro. Has no effect on a panel of seven other methyltransferases, including SETD7.

Product Specifications for WDR5 0103

Molecular Weight

383.44

Formula

C21H25N3O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-[(3-Methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)benzoic acid methyl ester

CAS Number

890190-22-4

PubChem ID

6457069

InChI Key

ZPLBXOVTSNRBFB-UHFFFAOYSA-N

SMILES

O=C(OC)C1=CC(NC(C3=CC=CC(OC)=C3)=O)=C(N2CCN(C)CC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.34 100
Ethanol 19.17 50

Preparing Stock Solutions for WDR5 0103

The following data is based on the product molecular weight 383.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.04 mL 26.08 mL
5 mM 0.52 mL 2.61 mL 5.22 mL
10 mM 0.26 mL 1.30 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for WDR5 0103

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for WDR5 0103

For research use only

Related Research Areas

Epigenetics

Customer Reviews for WDR5 0103 (1)

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  • WDR5-0103 is a small-molecule antagonist of WDR5
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: nih3t3
    Verified Customer | Posted 01/26/2023
    Reaction mixtures with various concentrations of WDR5-0103 (1 μM–1 mM) were incubated for 1 h at room temperature and then quenched by adding 20 μL of 7.5 M guanidinium chloride.

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