Catalog Number: 2339
Alternate Names: Apafant
Chemical Name: 4-[3-[4[(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a]diazepin-2-yl]-1-oxopropyl]morpholine
Biological Activity
Potent, selective platelet-activating factor (PAF) receptor antagonist (Ki = 16.3 nM). Displays anti-inflammatory, antiangiogenic and anticancer activity. Inhibits growth and proliferation of MCF-7 breast cancer cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol with gentle warming
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characterization of PAF receptors on human neutrophils using the specific antagonist, WEB 2086.
    Dent et al.
    FEBS Lett., 1989;244:365
  2. Effects of WEB 2086 on the protective role of preconditioning against arrhythmias in rats.
    Sariahmetoglu et al.
    Pharmacol.Res., 1998;38:173
  3. Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086.
    Cellai et al.
    Br.J.Cancer, 2006;94:1637
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