Potent and selective Lck and Src inhibitor (IC50
values are 2 and 6 nM respectively). Exhibits >300-fold selectivity against p38α
and KDR. Also potently inhibits SIK (IC50
values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases. Supports self-renewal of naive hESCs in combination with PD 0325901
, CHIR 99021
and SB 590885
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Systematic identification of culture conditions for induction and maintenance of naive human pluripotency.
Theunissen et al.
Cell Stem Cell, 2014;15:471
Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages.
Clark et al.
Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.
Martin et al.