WH-4-023

Catalog # Availability Size / Price Qty
5413/10
5413/50
WH-4-023 | CAS No. 837422-57-8 | Src Family Kinase Inhibitors
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Description: Potent and selective Lck and Src inhibitor; also inhibits SIK
Alternative Names: KIN112

Chemical Name: 2,6-Dimethylphenyl-N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate

Purity: ≥98%

Product Details
Citations (3)
Reviews

Biological Activity

WH-4-023 is a potent and selective Lck and Src inhibitor (IC50 values are 2 and 6 nM respectively). Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases. Supports self-renewal of naive hESCs in combination with PD 0325901, CHIR 99021 and SB 590885.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of WH-4-023 is reviewed on the chemical probes website.

Technical Data

M.Wt:
568.67
Formula:
C32H36N6O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
837422-57-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for WH-4-023

The citations listed below are publications that use Tocris products. Selected citations for WH-4-023 include:

3 Citations: Showing 1 - 3

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