Chemical Name: 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime
Biological ActivitySB 590885 is a potent B-Raf inhibitor (Kd = 0.3 nM). Selective for B-Raf against 46 other kinases (Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively). Decreases anchorage-independent growth of melanoma cell lines. Inhibits ERK phosphorylation and proliferation in tumor cells expressing B-RafV600E. The compound can be used in protocols for the chemical reprogramming of somatic cells to iPSCs.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.
King et al.
Cancer Res., 2006;66:11100
The identification of potent and selective imidazole-based inhibitors of B-Raf kinase.
Takle et al.
Citations for SB 590885
The citations listed below are publications that use Tocris products. Selected citations for SB 590885 include:
3 Citations: Showing 1 - 3
Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.
Authors: Najm Et al.
PLoS One 2015;522:216
Resistance to vemurafenib resulting from a novel mutation in the BRAFV600E kinase domain.
Authors: Wagenaar Et al.
Pigment Cell Melanoma Res 2014;27:124
A modified HSP70 inhibitor shows broad activity as an anticancer agent.
Authors: Balaburski Et al.
Mol Cancer Res 2013;11:219
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