SB 590885

Tocris Bioscience | Catalog # 2650

Potent B-Raf inhibitor
Tocris Bioscience

Key Product Details

Description

Potent B-Raf inhibitor
View all Raf Kinase Inhibitors »

Product Description

SB 590885 is a potent B-Raf inhibitor (Kd = 0.3 nM). Selective for B-Raf against 46 other kinases (Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively). Decreases anchorage-independent growth of melanoma cell lines. Inhibits ERK phosphorylation and proliferation in tumor cells expressing B-RafV600E. The compound can be used in protocols for the chemical reprogramming of somatic cells to iPSCs.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Product Specifications for SB 590885

Molecular Weight

453.54

Formula

C27H27N5O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime

CAS Number

405554-55-4

PubChem ID

11316960

InChI Key

DPCXEUSDRQOOGZ-QLYXXIJNSA-N

SMILES

CN(C)CCOC(C=C4)=CC=C4C1=NC(C3=CC=C(C(CC5)=NO)C5=C3)=C(C2=CC=NC=C2)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.54 10

Preparing Stock Solutions for SB 590885

The following data is based on the product molecular weight 453.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.05 mL 110.24 mL 220.49 mL
0.5 mM 4.41 mL 22.05 mL 44.10 mL
1 mM 2.20 mL 11.02 mL 22.05 mL
5 mM 0.44 mL 2.20 mL 4.41 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 50 publications citing the usage of this product.

Product Documents for SB 590885

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SB 590885

For research use only

Customer Reviews for SB 590885 (1)

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  • Great effect
    Name: Raj Kumar
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Endothelial cell
    Verified Customer | Posted 03/18/2021
    Endothelial cells were subjected to pre-treatment with 0.05 micromole SB 590885 prior to FGF2 treatment, isolated protein, and immunoblotted for pMEK1 levels.
    SB 590885 2650

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