SB 590885 (CAS 405554-55-4): R&D Systems
Catalog Number: 2650
Chemical Name: 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime
Biological Activity
Potent B-Raf inhibitor (Kd = 0.3 nM). Selective for B-Raf against 46 other kinases (Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively). Decreases anchorage-independent growth of melanoma cell lines. Inhibits ERK phosphorylation and proliferation in tumor cells expressing B-RafV600E.
Technical Data
  • M.Wt:
    453.54
  • Formula:
    C27H27N5O2
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    405554-55-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline.
Background References
  1. Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.
    King et al.
    Cancer Res., 2006;66:11100
  2. The identification of potent and selective imidazole-based inhibitors of B-Raf kinase.
    Takle et al.
    Bioorg.Med.Chem.Lett., 2006;16:378
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 590885 include:

3 Citations: Showing 1 - 3
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  1. Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.
    Authors: Najm Et al.
    PLoS One 2015;522:216
  2. Resistance to vemurafenib resulting from a novel mutation in the BRAFV600E kinase domain.
    Authors: Wagenaar Et al.
    Pigment Cell Melanoma Res 2014;27:124
  3. A modified HSP70 inhibitor shows broad activity as an anticancer agent.
    Authors: Balaburski Et al.
    Mol Cancer Res 2013;11:219

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