WHI-P 154

Catalog # Availability Size / Price Qty
3115/5
3115/25
WHI-P 154 | CAS No. 211555-04-3 | JAK Kinase Inhibitors
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Description: JAK3 kinase inhibitor. Also inhibits EGFR

Chemical Name: 2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol

Purity: ≥99%

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Biological Activity

JAK3 inhibitor (IC50 = 1.8 μM) that displays no activity at JAK1 or JAK2. Inhibits STAT1 activation, iNOS expression and NO production in macrophages in vitro. Also inhibits other common kinases including EGFR (IC50 = 4 nM), Src, Abl, VEGFR, MAPK and PI 3-K and induces apoptosis in human glioblastoma cell lines (IC50 = 158 μM). Induces differentiation of neural progenitor cells.

Technical Data

M.Wt:
376.2
Formula:
C16H14BrN3O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
211555-04-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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