WIC1

Key Product Details

Product Description

WIC1 is an inhibitor of the canonical Wnt/β-catenin signaling pathway. In vitro, it reduces ABSC (Airway Basal Stem Cell) proliferation and induces ciliated epithelial cell differentiation, in a model of squamous lung cancer. WIC1 also represses the phosphorylation of β-catenin^Y489 and Tp63 expression.

Product Specifications for WIC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for WIC1

The following data is based on the product molecular weight 377.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.02 mM	132.47 mL	662.36 mL	1,324.71 mL
0.1 mM	26.49 mL	132.47 mL	264.94 mL
0.2 mM	13.25 mL	66.24 mL	132.47 mL
1 mM	2.65 mL	13.25 mL	26.49 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Aros High-throughput drug screening identifies a potent Wnt inhibitor that promotes airway basal stem cell homeostasis. Cell Rep. 2020 PMID: 32075752

Product Documents for WIC1