Inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2) (IC50
= 0.3 μ
M). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis.
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Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis.
Amory et al.
Suppression of Stra8 expression in the mouse gonad by WIN 18,446.
Hogarth et al.