Chemical Name: N,N'-1,8-Octanediylbis(2,2-dichloroacetamide)
Biological ActivityWIN 18446 is an inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2) (IC50 = 0.3 μM). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis.
Amory et al.
Suppression of Stra8 expression in the mouse gonad by WIN 18,446.
Hogarth et al.
Citation for WIN 18446
The citations listed below are publications that use Tocris products. Selected citations for WIN 18446 include:
1 Citation: Showing 1 - 1
Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration.
Authors: Barrionuevo Et al.
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This was used to inhibit recombinant Aldh1a2 activity in a titration curve.