Catalog Number: 4736
Chemical Name: N,N'-1,8-Octanediylbis(2,2-dichloroacetamide)
Biological Activity
Inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2) (IC50 = 0.3 μM). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis.
Technical Data
  • M.Wt:
    366.11
  • Formula:
    C12H20Cl4N2O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Storage:
    Store at +4°C
  • CAS No:
    1477-57-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis.
    Amory et al.
    J.Androl., 2011;32:111
  2. Suppression of Stra8 expression in the mouse gonad by WIN 18,446.
    Hogarth et al.
    Biol.Reprod., 2011;84:957

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