Catalog Number: 1799
Alternate Names: W-peptide
Biological Activity
Selective agonist for the formyl peptide receptors FPR2 and FPR3, expressed on immune cells. EC50 values for induction of calcium mobilization in FPR2-HL-60 cells and FPR3-HL-60 cells are 2 and 80 nM respectively.
Technical Data
  • M.Wt:
    856.11
  • Formula:
    C41H61N9O7S2
  • Sequence:
    WKYMVM

    (Modifications: Met-6 = C-terminal amide)

  • Solubility:
    Soluble to 0.60 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    187986-11-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of the peptides that stimulate the phosphoinositide hydrolysis in lymphocyte cell lines from peptide libraries.
    Baek et al.
    J.Biol.Chem., 1996;271:8170
  2. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/Lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2.
    Christophe et al.
    J.Biol.Chem., 2001;276:21585
  3. Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1 /LXA4R, is not affected by lipoxin.
    Christophe et al.
    Scand.J.Immunol., 2002;56:470
Citations:

The citations listed below are publications that use Tocris products. Selected citations for WKYMVM include:

3 Citations: Showing 1 - 3
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  1. Antagonism of human formyl peptide receptor 1 (FPR1) by chromones and related isoflavones.
    Authors: Schepetkin Et al.
    Biochem Pharmacol 2014;92:627
  2. 3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: molecular modeling of chiral recognition by FPR2.
    Authors: Schepetkin Et al.
    Biochem Pharmacol 2013;85:404
  3. Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors.
    Authors: Schepetkin Et al.
    Mol Pharmacol 2011;79:77

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