Catalog Number: 1799
Alternate Names: W-peptide
Biological Activity
Selective agonist for the formyl peptide receptors FPR2 and FPR3, expressed on immune cells. EC50 values for induction of calcium mobilization in FPR2-HL-60 cells and FPR3-HL-60 cells are 2 and 80 nM respectively.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Met-6 = C-terminal amide)

  • Solubility:
    Soluble to 0.60 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of the peptides that stimulate the phosphoinositide hydrolysis in lymphocyte cell lines from peptide libraries.
    Baek et al.
    J.Biol.Chem., 1996;271:8170
  2. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/Lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2.
    Christophe et al.
    J.Biol.Chem., 2001;276:21585
  3. Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1 /LXA4R, is not affected by lipoxin.
    Christophe et al.
    Scand.J.Immunol., 2002;56:470
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