Home / Formyl Peptide Receptor Agonists / WKYMVM

WKYMVM

Catalog #: 1799
5 Citations Datasheet / COA / SDS

Discontinued Product

1799 has been discontinued.
View all Formyl Peptide Receptor Agonists products.
WKYMVM
1 Image
Description: Selective FPR2 and FPR3 receptor agonist
Alternative Names: W-peptide
Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

WKYMVM is a selective agonist for the formyl peptide receptors FPR2 and FPR3, expressed on immune cells. EC50 values for induction of calcium mobilization in FPR2-HL-60 cells and FPR3-HL-60 cells are 2 and 80 nM respectively.

Technical Data

M.Wt:
856.11
Formula:
C41H61N9O7S2
Sequence:
WKYMVM

(Modifications: Met-6 = C-terminal amide)

Solubility:
Soluble to 0.60 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
187986-11-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Neutrophil stunning by metoprolol reduces infarct size
    J García-Pri, R Villena-Gu, M Gómez, E Bernardo, A Pun-García, I García-Lun, G Crainiciuc, R Fernández-, V Sreeramkum, R Bourio-Mar, JM García-Rui, AS Del Valle, D Sanz-Rosa, G Pizarro, A Fernández-, A Hidalgo, V Fuster, B Ibanez
    Nat Commun, 2017;8(0):14780.
  2. Identification of the peptides that stimulate the phosphoinositide hydrolysis in lymphocyte cell lines from peptide libraries.
    Baek et al.
    J.Biol.Chem., 1996;271:8170
  3. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/Lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2.
    Christophe et al.
    J.Biol.Chem., 2001;276:21585
  4. Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1 /LXA4R, is not affected by lipoxin.
    Christophe et al.
    Scand.J.Immunol., 2002;56:470

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for WKYMVM

The citations listed below are publications that use Tocris products. Selected citations for WKYMVM include:

5 Citations: Showing 1 - 5

  1. Neutrophils self-limit swarming to contain bacterial growth in vivo
    Authors: Kienle Et al.
    Science  2021;372
  2. Neutrophil stunning by MP reduces infarct size.
    Authors: García-Prieto Et al.
    Nat Commun  2017;8:14780
  3. Antagonism of human formyl peptide receptor 1 (FPR1) by chromones and related isoflavones.
    Authors: Schepetkin Et al.
    Biochem Pharmacol  2014;92:627
  4. 3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: molecular modeling of chiral recognition by FPR2.
    Authors: Schepetkin Et al.
    Biochem Pharmacol  2013;85:404
  5. Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors.
    Authors: Schepetkin Et al.
    Mol Pharmacol  2011;79:77

FAQs

No product specific FAQs exist for this product, however you may

View all Peptide FAQs

Reviews for WKYMVM

There are currently no reviews for this product. Be the first to review WKYMVM and earn rewards!

Have you used WKYMVM?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.