Catalog Number: 1800
Alternate Names: Leukocyte chemoattractant peptide
Biological Activity
Selective agonist for the formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM) and FPR3 (EC50 = 3 nM), expressed on immune cells. Induces Ca2+ mobilization and superoxide production in, and chemotaxic migration of, monocytes and neutrophils. Also promotes monocyte survival through a PKC-, PI 3-kinase- and Akt-dependent pathway.
Technical Data
  • M.Wt:
    856.11
  • Formula:
    C41H61N9O7S2
  • Sequence:
    WKYMVM

    (Modifications: Met-6 = D-Met & C-terminal amide)

  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    187986-17-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The synthetic chemoattractant peptide, Trp-Lys-Tyr-Met-Val-D-Met, enhances monocyte survival via PKC-dependent Akt activation.
    Bae et al.
    J.Leukoc.Biol., 2002;71:329
  2. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/Lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2.
    Christophe et al.
    J.Biol.Chem., 2001;276:21585
  3. Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and fomyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activation.
    Le et al.
    J.Immunol., 1999;163:6777
Citations:

The citations listed below are publications that use Tocris products. Selected citations for WKYMVm include:

2 Citations: Showing 1 - 2
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  1. Identification of a Novel Recycling Sequence in the C-tail of FPR2/ALX Receptor: ASSOCIATION WITH CELL PROTECTION FROM APOPTOSIS.
    Authors: Thompson Et al.
    J Biol Chem 2014;289:36166
  2. Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2.
    Authors: Khau Et al.
    Invest Ophthalmol Vis Sci 2011;25:483

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