WY 14643

  ( 9 citations )    
Product Datasheet
Catalog Number:1312
Chemical Name:[[4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]acetic acid
Product Details
Citations (9)
Supplemental Products
Reviews
Biological Activity
Selective PPARα agonist (EC50 values are 0.63, 32 and > 100 μM at PPARα, PPARγ and PPARδ respectively). Negatively inhibits NF-κB transcriptional activity and decreases the inflammatory response in vitro and in vivo.
Technical Data
  • M.Wt:
    323.8
  • Formula:
    C14H14ClN3O2S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    50892-23-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for WY 14643 include:

9 Citations: Showing 1 - 9
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  1. Multifaceted Mechanisms of WY-14643 to Stabilize the Blood-Brain Barrier in a Model of Traumatic Brain Injury.
    Authors: Neuhaus Et al.
    Front Mol Neurosci  2017;10:149
  2. Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling.
    Authors: Oruqaj Et al.
    Proc Natl Acad Sci U S A  2015;112:E2048
  3. PPAR-alpha agonists as novel antiepileptic drugs: preclinical findings.
    Authors: Puligheddu Et al.
    PLoS One  2013;8:e64541
  4. Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis.
    Authors: Rizvi Et al.
    Vascul Pharmacol  2013;59:144
  5. Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors.
    Authors: Mascia Et al.
    Biol Psychiatry  2011;69:633
  6. 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated
    Authors: Bumpus and Johnson
    Mol Psychiatry  2011;339:886
  7. Rapid non-genomic regulation of Ca2+ signals and insulin secretion by PPAR alpha ligands in mouse pancreatic islets of Langerhans.
    Authors: Ropero Et al.
    J Endocrinol  2009;200:127
  8. Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors.
    Authors: Melis Et al.
    J Neurosci  2008;28:13985
  9. Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level.
    Authors: Lee Et al.
    Biochem J  2004;378:983

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