Catalog Number: 1312
Chemical Name: [[4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]acetic acid
Biological Activity
Selective PPARα agonist (EC50 values are 0.63, 32 and > 100 μM at PPARα, PPARγ and PPARδ respectively). Negatively inhibits NF-κB transcriptional activity and decreases the inflammatory response in vitro and in vivo.
Technical Data
  • M.Wt:
    323.8
  • Formula:
    C14H14ClN3O2S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    50892-23-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The PPARs: from orphan receptors to drug discovery.
    Willson et al.
    J.Med.Chem., 2000;43:527
  2. Peroxisome proliferator-activated receptors in the cardiovascular system.
    Bishop-Bailey
    Br.J.Pharmacol., 2000;129:823
  3. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ.
    Forman et al.
    Proc.Natl.Acad.Sci.U.S.A., 1997;94:4312

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