WY 14643

Catalog # Availability Size / Price Qty
1312/10
1312/50
WY 14643 | CAS No. 50892-23-4 | PPAR alpha Receptor Agonists
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Description: Selective PPARα agonist

Chemical Name: [[4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]acetic acid

Purity: ≥98%

Product Details
Citations (12)
Supplemental Products
Reviews

Biological Activity

Selective PPARα agonist (EC50 values are 0.63, 32 and > 100 μM at PPARα, PPARγ and PPARδ respectively). Negatively inhibits NF-κB transcriptional activity and decreases the inflammatory response in vitro and in vivo.

Technical Data

M.Wt:
323.8
Formula:
C14H14ClN3O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
50892-23-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for WY 14643

The citations listed below are publications that use Tocris products. Selected citations for WY 14643 include:

12 Citations: Showing 1 - 10

  1. Short-Term Activation of Peroxisome Proliferator-Activated Receptors α and γ Induces Tissue-Specific Effects on Lipid Metabolism and Fatty Acid Composition in Male Wistar Rats.
    Authors: Strand Et al.
    PPAR Res  2019;2019:8047627
  2. Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties.
    Authors: Smith Et al.
    Psychopharmacology (Berl)  2019;
  3. Peroxisome Proliferator-Activated Receptor α Agonist and Its Target Nanog Cooperate to Induce Pluripotency.
    Authors: Lee Et al.
    J Clin Med  2018;7
  4. Multifaceted Mechanisms of WY-14643 to Stabilize the Blood-Brain Barrier in a Model of Traumatic Brain Injury.
    Authors: Neuhaus Et al.
    Front Mol Neurosci  2017;10:149
  5. Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling.
    Authors: Oruqaj Et al.
    Proc Natl Acad Sci U S A  2015;112:E2048
  6. PPAR-alpha agonists as novel antiepileptic drugs: preclinical findings.
    Authors: Puligheddu Et al.
    PLoS One  2013;8:e64541
  7. Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis.
    Authors: Rizvi Et al.
    Vascul Pharmacol  2013;59:144
  8. Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors.
    Authors: Mascia Et al.
    Biol Psychiatry  2011;69:633
  9. 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated
    Authors: Bumpus and Johnson
    Mol Psychiatry  2011;339:886
  10. Rapid non-genomic regulation of Ca2+ signals and Ins secretion by PPAR alpha ligands in mouse pancreatic islets of Langerhans.
    Authors: Ropero Et al.
    J Endocrinol  2009;200:127

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