Catalog Number: 2491
Alternate Names: SR 57746A
Chemical Name: 1,2,3,6-Tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-pyridine hydrochloride
Biological Activity
Orally active, full agonist at 5-HT1A receptors. Binds rat 5-HT1A with high affinity (Ki = 2.0 nM) and is > 300-fold selective over other 5-HT receptor subtypes (IC50 > 650 nM). Increases motoneuron survival and promotes effects of NGF on neurite outgrowth in vitro. Displays neurotrophic activity in several neurodegenerative models in vivo.�.
Technical Data
  • M.Wt:
    417.9
  • Formula:
    C24H22F3N.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    90494-79-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Protective effects of SR 57746A in central and peripheral models of neurodegenerative disorders in rodents and primates.
    Fournier et al.
    Neuroscience, 1993;55:629
  2. Effect of the nonpeptide neurotrophic compound SR 57746A on the phenotypic survival of purified mouse motoneurons.
    Duong et al.
    Br.J.Pharmacol., 1999;128:1385
  3. Biochemical and electrophysiological properties of SR 57746A, a new, potent 5-HT1A receptor agonist.
    Bachy et al.
    Fund.Clin.Pharmacol., 1993;7:487

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