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Xaliproden hydrochloride

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Xaliproden hydrochloride | CAS No. 90494-79-4 | 5-HT1 Receptor Agonists
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Description: High affinity 5-HT1A agonist; orally active
Alternative Names: SR 57746A

Chemical Name: 1,2,3,6-Tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-pyridine hydrochloride

Purity: ≥99%

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Biological Activity

Orally active, full agonist at 5-HT1A receptors. Binds rat 5-HT1A with high affinity (Ki = 2.0 nM) and is > 300-fold selective over other 5-HT receptor subtypes (IC50 > 650 nM). Increases motoneuron survival and promotes effects of NGF on neurite outgrowth in vitro. Displays neurotrophic activity in several neurodegenerative models in vivo..

Technical Data

M.Wt:
417.9
Formula:
C24H22F3N.HCl
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
90494-79-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Protective effects of SR 57746A in central and peripheral models of neurodegenerative disorders in rodents and primates.
    Fournier et al.
    Neuroscience, 1993;55:629
  2. Effect of the nonpeptide neurotrophic compound SR 57746A on the phenotypic survival of purified mouse motoneurons.
    Duong et al.
    Br.J.Pharmacol., 1999;128:1385
  3. Biochemical and electrophysiological properties of SR 57746A, a new, potent 5-HT1A receptor agonist.
    Bachy et al.
    Fund.Clin.Pharmacol., 1993;7:487

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VersaClone cDNA Plasmids

Human 5-HT1A (NP_000515) VersaClone cDNA

RDC0283

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