Chemical Name: 1,2,3,6-Tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-pyridine hydrochloride
Biological ActivityOrally active, full agonist at 5-HT1A receptors. Binds rat 5-HT1A with high affinity (Ki = 2.0 nM) and is > 300-fold selective over other 5-HT receptor subtypes (IC50 > 650 nM). Increases motoneuron survival and promotes effects of NGF on neurite outgrowth in vitro. Displays neurotrophic activity in several neurodegenerative models in vivo..
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Protective effects of SR 57746A in central and peripheral models of neurodegenerative disorders in rodents and primates.
Fournier et al.
Effect of the nonpeptide neurotrophic compound SR 57746A on the phenotypic survival of purified mouse motoneurons.
Duong et al.
Biochemical and electrophysiological properties of SR 57746A, a new, potent 5-HT1A receptor agonist.
Bachy et al.
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