Xaliproden hydrochloride

Key Product Details

Product Description

Xaliproden hydrochloride is an orally active, full agonist at 5-HT_1A receptors. Binds rat 5-HT_1A with high affinity (K_i = 2.0 nM) and is > 300-fold selective over other 5-HT receptor subtypes (IC₅₀ > 650 nM). Increases motoneuron survival and promotes effects of NGF on neurite outgrowth in vitro. Displays neurotrophic activity in several neurodegenerative models in vivo..

Product Specifications for Xaliproden hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Xaliproden hydrochloride

The following data is based on the product molecular weight 417.90.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.39 mL	11.96 mL	23.93 mL
5 mM	0.48 mL	2.39 mL	4.79 mL
10 mM	0.24 mL	1.20 mL	2.39 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Duong Effect of the nonpeptide neurotrophic compound SR 57746A on the phenotypic survival of purified mouse motoneurons. Br.J.Pharmacol. 1999 PMID: 10602316
• Bachy Biochemical and electrophysiological properties of SR 57746A, a new, potent 5-HT_1A receptor agonist. Fund.Clin.Pharmacol.
• Fournier Protective effects of SR 57746A in central and peripheral models of neurodegenerative disorders in rodents and primates. Neuroscience 1993 PMID: 8413926

Product Documents for Xaliproden hydrochloride