Xaliproden hydrochloride

   
Product Datasheet
Catalog Number:2491
Alternate Names:SR 57746A
Chemical Name:1,2,3,6-Tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-pyridine hydrochloride
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Biological Activity
Orally active, full agonist at 5-HT1A receptors. Binds rat 5-HT1A with high affinity (Ki = 2.0 nM) and is > 300-fold selective over other 5-HT receptor subtypes (IC50 > 650 nM). Increases motoneuron survival and promotes effects of NGF on neurite outgrowth in vitro. Displays neurotrophic activity in several neurodegenerative models in vivo..
Technical Data
  • M.Wt:
    417.9
  • Formula:
    C24H22F3N.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    90494-79-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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